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Modeling the impact of vaccination for the immunization Agenda 2030: Deaths averted due to vaccination against 14 pathogens in 194 countries from 2021 to 2030
Vaccine. 2023 Aug 1:S0264-410X(23)00854-X. doi: 10.1016/j.vaccine.2023.07.033. Online ahead of print.ABSTRACTBACKGROUND: The Immunization Agenda 2030 (IA2030) Impact Goal 1.1. aims to reduce the number of future deaths averted through immunization in the next decade. To estimate the potential impact of the aspirational coverage targets for IA2030, we developed an analytical framework and estimated the number of deaths averted due to an ambitious vaccination coverage scenario from 2021 to 2030 in 194 countries.METHOD: A demographic model was used to determine annual age-specific mortality estimates associated with vaccine c...
Source: Vaccine - August 3, 2023 Category: Allergy & Immunology Authors: Austin Carter William Msemburi So Yoon Sim Katy A M Gaythorpe Philipp Lambach Ann Lindstrand Raymond Hutubessy Source Type: research

Spread of multidrug resistance in non-PCV13/PCV20 serotypes of Streptococcus pneumoniae: A cross-sectional study ten years after the introduction of pneumococcal conjugate vaccine in Japan
J Microbiol Immunol Infect. 2023 Jul 20:S1684-1182(23)00123-8. doi: 10.1016/j.jmii.2023.07.004. Online ahead of print.ABSTRACTTen years after the introduction of the pneumococcal conjugate vaccine (PCV) in Japan, the prevalence rates of non-PCV13 and non-PCV20 serotypes among pediatric pneumococcal isolates were 94.0% and 73.7%, respectively. The predominant non-PCV13/PCV20 serotypes (15A, 35B, and 23A) were mostly multidrug-resistant (≥80.5%), exhibiting non-susceptibility to penicillin.PMID:37517964 | DOI:10.1016/j.jmii.2023.07.004
Source: Journal of Microbiology, Immunology, and Infection - July 30, 2023 Category: Microbiology Authors: Mitsuyo Kawaguchiya Noriko Urushibara Meiji Soe Aung Nobuhide Ohashi Rika Takamatsu Sho Tsutida Masahiko Ito Nobumichi Kobayashi Source Type: research

Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine in Japanese healthy infants: A phase III study (V114-033)
CONCLUSION: In Japanese infants, a four-dose series of V114 was generally well tolerated. Compared with PCV13, V114 provided non-inferior immune responses to the 13 shared serotypes and higher immune responses to serotype 22F and 33F post-primary series.TRIAL REGISTRATION: ClinicalTrials.gov: NCT04384107; EudraCT 2019-003644-68.PMID:37344262 | DOI:10.1016/j.vaccine.2023.05.064
Source: Vaccine - June 21, 2023 Category: Allergy & Immunology Authors: Hiroko Suzuki Hidetoshi Fujita Kazuyuki Iwai Haruo Kuroki Kazuhiko Taniyama Toshiyuki Shizuya Hiroyuki Kishino Rie Igarashi Masayoshi Shirakawa Miyuki Sawata Source Type: research

Pneumonia hospitalization after introduction of pneumococcal conjugate vaccine in Japan: Descriptive study using a nationwide claims database
CONCLUSION: Our study estimated 4-6 pneumonia hospitalizations per 1000 pediatric population in Japan, with a 34 % decrease after the introduction of PCV. This study examined the nationwide effectiveness of PCV, further studies are needed in all age groups.PMID:37286407 | DOI:10.1016/j.vaccine.2023.05.065
Source: Vaccine - June 7, 2023 Category: Allergy & Immunology Authors: Takanori Yanai Satomi Yoshida Masato Takeuchi Koji Kawakami Source Type: research

Association of pneumococcal vaccination with cardiovascular diseases in older adults: The vaccine effectiveness, networking, and universal safety (VENUS) study
This study aimed to investigate the protective effect of PPSV23 on cardiovascular events in adults aged ≥ 65 years. This population-based nested case-control study was conducted using the claims data and vaccine records between April 2015 and March 2020 from the Vaccine Effectiveness, Networking, and Universal Safety (VENUS) Study. PPSV23 vaccination was identified using vaccination records in each municipality. The primary outcome was acute myocardial infarction (AMI) or stroke. The adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for PPSV23 vaccination were calculated using conditional logistic regressio...
Source: Vaccine - March 4, 2023 Category: Allergy & Immunology Authors: Nobuhiro Narii Tetsuhisa Kitamura Sho Komukai Ling Zha Masayo Komatsu Fumiko Murata Megumi Maeda Kosuke Kiyohara Tomotaka Sobue Haruhisa Fukuda Source Type: research

Single-centre, cross-sectional study on the factors and reasons for non-vaccination among patients with rheumatoid arthritis
CONCLUSIONS: We found that the factors associated with non-vaccination varied by vaccine type; therefore, vaccinations should be promoted with individualised strategies.PMID:36702156 | DOI:10.1093/mr/road003
Source: Herpes - January 26, 2023 Category: Infectious Diseases Authors: Hirofumi Miyake Ryuichi Minoda Sada Yukio Tsugihashi Kazuhiro Hatta Source Type: research

Frequent Transmission of Streptococcus pneumoniae Serotype 35B and 35D, Clonal Complex 558 Lineage, across Continents and the Formation of Multiple Clades in Japan
Antimicrob Agents Chemother. 2023 Jan 18:e0108322. doi: 10.1128/aac.01083-22. Online ahead of print.ABSTRACTStreptococcus pneumoniae is a common bacterial pathogen that causes infections in children worldwide, even after administration of the pneumococcal conjugate vaccine. S. pneumoniae serotype 35B, especially the clonal complex 558 (CC558) lineage, has emerged globally following implementation of the 13-valent pneumococcal conjugate vaccine. Serotype 35B strains are also associated with multidrug resistance to both β-lactams and non-β-lactam drugs. In addition, a novel serotype, 35D, which is closely related to 35B an...
Source: Antimicrobial Agents and Chemotherapy - January 18, 2023 Category: Microbiology Authors: Koh Shinohara Takao Fujisawa Bin Chang Yutaka Ito Shigeru Suga Yasufumi Matsumura Masaki Yamamoto Miki Nagao Makoto Ohnishi Motoyuki Sugai Satoshi Nakano Source Type: research

Long-term efficacy and safety profile of splenectomy for pediatric chronic immune thrombocytopenia
Int J Hematol. 2023 Jan 9. doi: 10.1007/s12185-022-03529-z. Online ahead of print.ABSTRACTThere are few reports of the long-term efficacy of splenectomy in children with immune thrombocytopenia (ITP). In a 33-year period, we performed splenectomies in 23 pediatric patients with ITP at a single institution in Japan. The age at surgery was 5-22 years with a median of 10 years. The follow-up period was 1-141 months with a median of 48 months. Before surgery, we confirmed the presence or absence of the accessory spleen by contrast-enhanced CT scan and we recommended vaccination with pneumococcal vaccine. Four patients underwen...
Source: International Journal of Hematology - January 9, 2023 Category: Hematology Authors: Kyohei Isshiki Makiko Mori Tomoya Irikura Takahiro Ishikawa Mamoru Honda Ryota Kaneko Yuichi Mitani Hirohito Kubota Kohei Fukuoka Koichi Oshima Yuki Arakawa Katsuyoshi Koh Source Type: research

Factors and Reasons for Non-vaccination among Patients with Systemic Lupus Erythematosus: A Single-centre, Cross-sectional Study
Conclusion These findings, which demonstrated that the factors and reasons for non-vaccination varied by vaccine type, suggest that individualised strategies should be used to promote vaccination in this population.PMID:36575017 | DOI:10.2169/internalmedicine.1067-22
Source: Herpes - December 27, 2022 Category: Infectious Diseases Authors: Hirofumi Miyake Ryuichi Minoda Sada Atsushi Manabe Yukio Tsugihashi Kazuhiro Hatta Source Type: research

Associations of influenza and pneumococcal vaccinations with burdens of older family caregivers: The Japan Gerontological Evaluation study (JAGES) cross-sectional study
Vaccine. 2022 Dec 2:S0264-410X(22)01460-8. doi: 10.1016/j.vaccine.2022.11.047. Online ahead of print.NO ABSTRACTPMID:36470685 | DOI:10.1016/j.vaccine.2022.11.047
Source: Vaccine - December 5, 2022 Category: Allergy & Immunology Authors: Kousuke Iwai-Saito Koryu Sato Katsunori Kondo Source Type: research

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